产石杉碱甲新资源研究方法探索

摘要

Huperzine A recently serves as the first-line drug for treating Alzheimer's disease. This paper re-views the latest progress in source and development of Huperzine A from the comprehensive angles of drug needs and pharmaceutical industry. The development of transformation methods in future is prospected. Extraction from natural herbs, as the most convenient way for obtaining huperzine A, has a long history and still has great vitality. However, the method has been faced with a bottleneck of limited plant resources. Chemical synthesis is still one of the important ways for development of huperzine A, but it has the disadvantages of trivial steps, high cost and difficulty in obtaining composites with pure optical activity. Now, adopting biological techniques to obtain huperzine A from endophytic fun-gi and fermentation of H. serrata has been making great progress. It is recognized that utilizing biological techniques for transformation would become one of the important directions in industrial production of huperzine A.%从老年痴呆症药物需求研究到药物生产开发全方位视角对近期治疗老年痴呆症一线药物-石杉碱甲来源及生产的发展与动态进行综述，并对今后产石杉碱甲菌株研发方法进行了展望。源于天然植物的药物开发历史悠久且富有生命力，植物提取获得石杉碱甲为最简便方式，但植物提取获得石杉碱甲已面临植物资源匮乏瓶颈；化学合成生产石杉碱甲仍是研发重要途径之一，但合成步骤繁琐、代价昂贵，很难获得纯光学活性的合成物；利用从野生蛇足石杉内分离获得的内生真菌及其发酵液中提取石杉碱甲正在取得成效；依托生物技术改造菌株获得石杉碱甲将会是工业化生产开发的一个重要方向。