Objective To analyze baseline clinical characteristics of 1 094 acquired immunodeficiency syn-drome/human immunodeficiency virus (HIV/AIDS) patients with antiretroviral therapy (ART). Methods Baseline da-ta were collected from HIV/AIDS patients undergoing initial ART in Beijing Youan Hospital, Capital Medical Universi-ty from January 2013 to January 2014. Clinical features were analyzed. Results The study enrolled a total of 1 094 HIV/AIDS patients, including 1 012 males and 82 females, most of whom were 30~44 years old. Sex contact was the major HIV transmission route. The main symptoms were found to be fever, cough, sputum, fatigue, weight loss, etc. Op-portunistic infections mostly occurred in respiratory system (53.3%), followed by digestive system (28.9%). Morbidity of lung infection, PCP, oral fungal infection, herpes zoster, CMV retinitis and lymphoma in group of CD4+T cells<200 cells/µl were significantly higher than those in group of CD4+T cells≥200 cells/μl (P<0.05). Conclusion Clinical manifestations are complex and diverse in HIV/AIDS patients, and opportunistic infections mostly involve respiratory system. Closely observing symptoms and regularly testing CD4+T cell count are conducive to early prevention and con-trol of opportunistic infections and can improve the life quality of AIDS patients.%目的：研究基线时人免疫缺陷病毒(HIV)感染者/艾滋病(AIDS)患者的临床特点，为预防和控制艾滋病机会性感染提供依据。方法采集2013年1月至2014年1月在首都医科大学附属北京佑安医院感染中心随访并初次接受艾滋病抗逆转录病毒(ART)治疗的成年HIV/AIDS患者的基线资料并分析其临床特点。结果本研究共纳入1094例HIV/AIDS患者，其中男性1012例，女性82例，以30~44岁者居多，以性传播途径为主，主要临床表现为发热、咳嗽咳痰、乏力、消瘦等，其中呼吸系统机会性感染发生率达53.3%，其次为消化系统机会性感染(28.9%)。肺部感染、PCP、口腔真菌感染、带状疱疹、CMV视网膜炎和淋巴瘤的发生率在CD4<200个/μl组显著高于CD4≥200个/μl组，差异均有统计学意义(P<0.05)。结论艾滋病的临床表现复杂多样，机会性感染以呼吸系统最为常见，CD4细胞水平与机会性感染的发生密切相关。密切观察HIV/AIDS患者的临床症状，定期检测CD4细胞，有利于早期预防和控制机会性感染，提高HIV/AIDS患者的生活质量。
展开▼
