目的：探讨三七化瘀口服液对重症脓毒血症患者血流动力学和乳酸值的影响。方法将80例脓毒血症患者随机分为观察组和对照组，每组40例。所有患者均给予脓毒血症常规治疗，观察组在此基础上再给予三七化瘀口服液治疗，7d为一个疗程。比较两组患者治疗前后的血流动力学、血乳酸浓度、中医症候群积分和APACHEⅡ评分。结果治疗后两组患者的血流动力学均显著改善(P<0.01)，观察组患者治疗后血流动力学显著优于对照组(P<0.05)。两组患者治疗后血乳酸浓度均显著降低(P<0.01)，观察组患者治疗后各时点均显著低于对照组(P<0.05)。两组患者治疗后中医症候群积分和APACHEⅡ评分均显著降低(P<0.01)，观察组患者治疗后各时点均显著低于对照组(P<0.05)。结论三七化瘀口服液能改善低脓毒血症患者血流动力学并降低其血清乳酸值，改善患者临床症状，具有临床应用价值。%Objective To study the influence of notoginseng compound oral liquid on haemodynamics and serum lactate level in patients with severe sepsis. Methods A total of 80 patients with severe sepsis were randomly divided into study group and control group, with 40 patients in each group. All the patients were treated by routine therapy, and the patients in study group were additionally treated by notoginseng compound oral liquid, seven days as a course. The haemodynamics, serum lactate level, TCM syndrome integral score and APACHEⅡscore were com-pared. Results After treatment, the haemodynamics in both groups were significantly improved (P<0.01). The hae-modynamics in study group was significantly better than that in control group after treatment (P<0.05). After treat-ment, the serum lactate level in both groups were significantly decreased (P<0.01). The serum lactate level in study group was significantly lower than that in control group in all time points after treatment (P<0.05). After treatment the haemodynamics in both groups were significantly improved (P<0.01). The haemodynamics in study group was signifi-cantly better than that in control group in all time points after treatment (P<0.05). Conclusion Notoginseng com-pound oral liquid can improve haemodynamics and decrease serum lactate level in patients with severe sepsis, which makes it worth for clinical application.
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