三七化瘀口服液对外伤性股骨干闭合粉碎性骨折高危人群围术期的影响

摘要

目的 探讨三七化瘀口服液(三七、延胡索)对外伤性股骨干闭合粉碎性骨折高危人群围术期的影响.方法 将符合纳入标准的120例患者随机均分为治疗组和对照组,对照组采用低分子肝素钙注射液治疗,治疗组加用三七化瘀口服液,分别于术前、术后1、3、7d检测观察2组患者血清中白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)和D二聚体(D-D)水平及药物不良反应.结果 术前,2组患者血清中IL-6、TNF-α和D-D水平差异均无统计学意义;术后1d,2组患者血清中IL-6、TNF-α和D-D水平均呈升高趋势,升高程度相当,差异无明显统计学意义;术后3d,2组患者血清中IL-6、TNF-α和D-D水平开始呈下降趋势,且治疗组下降更明显,差异有统计学意义;术后7d,2组患者血清中IL-6、TNF-α和D-D水平均低于术前,且治疗组明显优于对照组,差异有统计学意义.结论 三七化瘀口服药能有效降低高危人群围术期IL-6、TNF-α和D-D水平,并可预防深静脉血栓形成.%AIM To investigate the effects of Sanqi Huayu Oral Liquid (Notoginseng Radix et Rhizoma,Corydalis Rhizoma) on femoral shaft comminuted fracture caused by trauma in perioperative period of high-risk groups.METHODS One hundred and twenty patients meeting the inclusion criteria were randomly and equally divided into treatment group and control group.The control group was treated by low molecular weight heparin calcium injection,while the treatment group was additionally given Sanqi Huayu Oral Liquid.Two groups' levels of serum IL-6,TNF-α and D-D were detected on pre-operation and the 1 st,3rd,7th after operation,respectively.Additionally,the adverse drug reactions were also observed.RESULTS There were no statistically significant differences in the levels of serum IL-6,TNF-α and D-D between the two groups before operation.The first day after operation,the levels of serum IL-6,TNF-α and D-D between the two groups showed increasing trends,which had similar elevated levels without statistically significant differences.The third day after operation,the levels of serum IL-6,TNF-α and D-D between the two groups presented downward trends,but those in the treatment group were decreased more markedly with statistically significant differences.Furthermore,the seventh day after operation,the levels of serum IL-6,TNF-α and D-D between the two groups were lower than those before the operation,and these indices in the treatment group were lower than those in the control group with statistically significant differences.CONCLUSION Sanqi Huayu Oral Liquid can not only effectively reduce the levels of serum IL-6,TNF-α and D-D in perioperative period of high-risk groups,but also prevent the formation of deep vein thrombosis.