变应性鼻炎致鼻出血患者不同治疗方案的临床效果研究

摘要

Objective To discuss the clinical effect of different treatments on nasal bleeding caused by aller-gic rhinitis. Methods Sixty-eight cases of patients with nasal bleeding caused by allergic rhinitis from March 2010 to July 2013 were selected and randomly divided into experimental group and control group (n=34). The control group was treated with adrenobazone tablet, levofloxacin hydrochloride eye ophthalmic gel and renault courtney nasal spray, while the experimental group was given additional impact immune therapy based on the treatment of the control group. The incidence of systemic adverse reactions and the changes of leukotriene B4 (LT-B4) before treatment and af-ter treatment in the two groups were compared at the second week, the fifth week and the eleventh week, and the clini-cal curative effects of two groups were compared as well. Results There was no statistical significance difference in the LT-B4 level before treatment between the experimental group and the control group. Compared to before treatment, the LT-B4 levels at the second week, the fifth week and the eleventh week after treatment were statistically significantly decreased both in the experimental group and the control group (P<0.05). There were no statistically significant differ-ence in the incidences of local reactions and adverse reactions between the experimental group and the control group (P>0.05). After treatment, the VAS scores at the second week, the fifth week and the eleventh week in the experimental group were statistically significantly lower than those in the control group (P<0.05). Conclusion Compared to conven-tional scheme, impact immune therapy is more effective in treating patients with nasal bleeding caused by allergic rhini-tis, meanwhile, it will not increase the incidence of adverse reactions and is worth of clinical application.%目的：探讨不同方案治疗变应性鼻炎致鼻出血的临床效果。方法选取我院2010年3月至2013年7月收治的68例变应性鼻炎致鼻出血患者，随机分成实验组和对照组各34例，对照组给予安络血片、盐酸左氧氟沙星眼用凝胶、雷诺考特喷鼻剂的常规治疗，实验组在对照组的基础上采用冲击免疫治疗方案，比较两组患者治疗前、治疗后第2周、第5周、第11周的全身不良反应发生率及白三烯-B4(LT-B4)的变化情况，同时比较两组的临床治疗效果。结果实验组的LT-B4水平在治疗前与对照组比较差异均无统计学意义(P>0.05)；实验组和对照组的LT-B4水平在治疗后第2周、第5周、第11周较治疗前均显著下降且差异均具有统计学意义(P<0.05)；实验组和对照组的局部不良反应发生率、全身不良反应发生率比较差异均无统计学意义(P>0.05)；实验组在治疗后第2周、第5周、第11周的VAS评分、IgG、IgM水平均明显低于对照组，差异均具有统计学意义(P<0.05)。结论采用冲击免疫治疗方案对变应性鼻炎致出血患者进行治疗的疗效较常规方案更优，同时不会增加不良反应的发生率，值得临床上推广应用。