Objective To investigate the relationship between reflux esophagitis and lower esophagus lesions of gastric fundus. Methods From January 2016 to June 2017, 200 cases of gastroesophageal reflux disease (GERD) patients, who admitted to Department of Gastroenterology of Puning Overseas Chinese Hospital, were selected as the research objects. The pathological changes of gastroesophageal reflux in patients with reflux esophagitis (RE) and Bar-rett's esophagus (BE) were observed under gastroscopy, and the clinical data of the patients were analyzed statistically. Results Among of 200 cases of GERD, there were 146 cases of RE (1 case of gastric fundus carcinoma), 54 cases of BE (1 case of severe dysplasia with the incidence rate of 1.85％, 1 case of esophageal carcinoma with the incidence rates of 1.85％). The rates of smoking, drinking and obesity in the BE group were 51.85％, 42.59％and 20.37％, respec-tively, which were significantly higher than corresponding 25.34％, 23.97％ and 10.27％ in the RE group (P<0.05). Conclusion The detection rate of reflux esophagitis is high, and BE is precancerous lesion of esophageal adenocarcino-ma, which is related to smoking, drinking and obesity.%目的 探讨反流性食管炎与食管下段胃底病变的关系.方法 选择2016年1月至2017年6月期间普宁华侨医院消化内科收治的200例胃食管反流病(GERD)患者为研究对象,胃镜下对反流性食管炎(RE)、Barrett食管(BE)患者的胃食管病变情况进行观察,并统计分析患者的临床资料.结果 200例GERD患者共检出RE患者146例(合并胃底癌1例),BE患者54例,BE患者中有中重度异型增生1例,食管腺癌1例,发生率分别为1.85％和1.85％.BE组患者吸烟、饮酒及肥胖的比例分别为51.85％、42.59％、20.37％,均明显高于RE组的25.34％、23.97％和10.27％,差异均有统计学意义(P<0.05).结论 反流性食管炎的检出率较高,而BE是食管腺癌的癌前病变,其发生与吸烟、饮酒及肥胖有关.
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