血清及房水中VEGF、IL-6与新生血管性青光眼的相关性

摘要

目的 探讨血清及房水中血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)与新生血管性青光眼(NVG)的关系.方法 选择2013年2月至2016年10月期间在湖北医药学院附属人民医院眼科接受治疗的NVG患者22眼为观察组,同期住院原发性慢性闭角型青光眼患者25眼为对照组,同期住院白内障患者25眼为正常组,比较三组患者血清及房水中VEGF、IL-6水平.结果 观察组患者血清与房水中VEGF、IL-6水平分别为(545.41±156.49)ng/mL、(292.23±23.65)pg/mL,明显高于对照组的(323.21±52.32)ng/mL、(105.23±15.21)pg/mL与正常组的(175.31±19.56)ng/mL、(88.23±12.78)pg/mL,而对照组患者血清与房水中VEGF、IL-6水平明显高于正常组,差异均有统计学意义(P<0.05);观察组患者仅房水中VEGF与IL-6呈显著正相关(r=0.629,P=0.007).结论 NVG患者血清及房水中VEGF、IL-6均显著升高,但仅房水中VEGF与IL-6呈显著正相关,高水平的VEGF、IL-6相互作用,能够促进新生血管的产生,进而导致NVG的发生.%Objective To discuss the relationship of serum and aqueous humor vascular endothelial growth fac-tor (VEGF) and IL-6 to neovascular glaucoma (NVG). Methods A total of 22 patients with NVG, who admitted to De-partment of Ophthalmology of People's Hospital Affiliated to Hubei University of Medicine from February 2013 to Octo-ber 2016, were selected as the observation group. Meantime, 25 patients with chronic primary angle-closure glaucoma and 25 patients with cataract were respectively enrolled as the control group and the normal group. The levels of VEGFand IL-6 in serum and aqueous humor of the three groups were contrasted and analyzed. Results The levels of VEGF and IL-6 in serum and aqueous humor in the observation group were (545.41±156.49) ng/mL and (292.23±23.65) pg/mL, respectively, which were significantly higher than (323.21±52.32) ng/mL and (105.23±15.21) pg/mL in the control group and (175.31±19.56) ng/mL and (88.23±12.78) pg/mL in the normal group (P<0.05);the levels of VEGF and IL-6 in se-rum and aqueous humor in the control group were significantly higher than the normal group (P<0.05). There was a sig-nificantly positive correlation between VEGF and IL-6 in aqueous humor in the observation group (r=0.629, P=0.007). Conclusion VEGF and IL-6 in serum and aqueous humor in patients with NVG are significantly increased, and there is a significantly positive correlation between VEGF and IL-6 in aqueous humor. The interaction of high levels of VEGF and IL-6 can promote angiogenesis, and lead to the occurrence of NVG.