血清PCT与hs-CRP对新生儿细菌感染性肺炎的诊断价值

摘要

Objective To compare the diagnostic value of serum calcitonin (PCT) and high sensitive C reactive protein (hs-CRP) in neonatal bacterial infectious pneumonia. Methods A total of 90 cases of neonatal pneumonia treat-ed from January 2015 to June 2016 in Longjiang Hospital of Shunde District in Foshan City as the research objects were divided into bacterial pneumonia group (n=46) and non-bacterial pneumonia group (n=44) according to the different pathogens. The positive rate of serum PCT and hs-CRP between the two groups were compared, as well as changes of positive rate of serum PCT and hs-CRP in bacterial pneumonia group after treatment. Results In bacterial pneumonia group, the positive rates of hs-CRP and PCT were 71.74%and 91.30%, which were significantly higher than 18.18%and 4.55% in non-bacterial pneumonia group (P<0.05). In bacterial pneumonia group, 1 week after treatment, the positive rate of PCT was 32.61%, and it was higher than 13.04%of hs-CRP (P<0.05). There were no statistically significant dif-ferences in the positive rate of PCT (4.35%) and hs-CRP (2.17%) 2 weeks after treatment (P>0.05). Conclusion It is of great value of serum PCT in the diagnosis and differential diagnosis of neonatal bacterial pneumonia, and PCT is helpful to evaluate the therapeutic effect and to guide the application of antibiotics.%目的 比较血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)对新生儿细菌感染性肺炎的诊断价值.方法 选择2015年1月至2016年6月期间我院收治的新生儿肺炎90例为研究对象,根据病原体的不同分为细菌性肺炎组(n=46)与非细菌性肺炎组(n=44),比较两组患儿血清PCT和hs-CRP阳性率,以及细菌性肺炎患儿治疗后血清PCT和hs-CRP阳性率的变化.结果 细菌性肺炎组患儿的hs-CRP、PCT阳性率分别为71.74%、91.30%,明显高于非细菌性肺炎组患儿的18.18%和4.55%,差异均有统计学意义(P<0.05);细菌性肺炎患儿治疗1周后,PCT阳性率为32.61%,高于hs-CRP的13.04%,差异均有统计学意义(P<0.05);治疗2周后PCT和hs-CRP阳性率分别为4.35%和2.17%,差异无统计学意义(P>0.05).结论 血清PCT对于新生儿细菌性肺炎具有更好的诊断及鉴别诊断价值,且PCT有助于评估治疗效果并指导抗菌药物的应用.