老年缺血性脑卒中患者高敏C反应蛋白水平与预后的关系

摘要

Objective To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and prognosis of elderly patients with ischemic stroke. Methods Sixty-eight elderly patients with acute isch-emic stroke treated in Neurology Department of our hospital were studied, and thirty healthy elderly persons with matched age and sex were included as the control group. According to the clinical neural function defect score (NDS), the ischemic stroke patients were divided into severe defect group (n=25), moderate defect group (n=28) and mild defect group (n=15); and 28 days after treatment, they were divided into poor prognosis group (n=19) and good prognosis group (n=49). According to the NDS, the NDS and the levels of serum hs-CRP in the different research groups were com-pared. Results The levels of serum hs-CRP in control group and mild defect group, moderate defect group and severe defect group were (2.56±1.08) mg/L, (6.14±2.19) mg/L, (8.79±2.46) mg/L and (12.13±3.71) mg/L, which increased grad-ually (P<0.05). NDS in mild defect group, moderate defect group and severe defect group were (12.56 ± 4.68), (19.65 ± 6.35) and (32.47 ± 12.89), which were increased gradually (P<0.05). The level of serum hs-CRP in the poor prognosis group was (13.01±3.94) mg/L, which was significantly higher than (9.28±2.88) in good prognosis group, showing statis-tically significant difference (P<0.05). Conclusion The level of serum hs-CRP can be as effective index of the severity and prognosis for elderly patients with ischemic stroke.%目的 探讨老年缺血性脑卒中患者血清高敏C反应蛋白(hs-CRP)水平与预后的关系.方法 选择2016年1~8月期间我院神经内科收治的68例老年急性缺血性脑卒中患者为研究对象,并选择同期年龄和性别相匹配的30例健康老年人纳入对照组;评估脑卒中患者临床神经功能缺损程度(NDS),将其分别纳入重度缺损组(n=25),中度缺损组(n=28)及轻度缺损组(n=15),并根据患者治疗28 d时的NDS情况将患者分别纳入预后不佳组(n=19)与预后良好组(n=49);比较不同组别受检者NDS及血清hs-CRP水平.结果 血清hs-CRP水平在对照组、轻度缺损组、中度缺损组及重度缺损组患者分别为(2.56±1.08)mg/L、(6.14±2.19)mg/L、(8.79±2.46)mg/L、(12.13±3.71)mg/L,其水平依次升高,差异有统计学意义(P<0.05);NDS评分在轻度缺损组、中度缺损组及重度缺损组患者中分别为(12.56±4.68)分、(19.65±6.35)分、(32.47±12.89)分,其水平依次升高,差异有统计学意义(P<0.05);预后不佳组患者血清hs-CRP水平为(13.01±3.94)mg/L,明显高于预后良好组的(9.28±2.88)mg/L,差异有统计学意义(P<0.05).结论 血清hs-CRP水平可以作为反映老年缺血性脑卒中患者病情严重程度及预后的客观指标.