小儿肺热咳喘口服液佐治支原体肺炎的疗效及其对患儿血清炎症因子的影响

摘要

Objective To investigate the efficacy of Xiaoer-feire-kechuan oral solution in the treatment of My-coplasma pneumoniae infection and its effect on serum inflammatory factors in children. Methods A total of 82 chil-dren with Mycoplasma pneumoniae infection, who admitted to Department of Pediatrics of our hospital from Jun. 2014 to Feb. 2016, were selected and randomly divided into the two groups according to the random number table method, with 41 cases in each group. The control group was treated with conventional azithromycin treatment, and the observation group was treated with Xiaoer-feire-kechuan oral solution. The course of treatment was 7 d. The clinical curative effect and serum C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were compared between two groups. Results The time of fever, pulmonary rales disappearance time, hospitalization time in the observation group were (2.56 ± 0.69) d, (5.83 ± 0.77) d, (7.69 ± 1.00) d, respectively, which were significantly shorter than (3.59 ± 1.24) d, (6.86 ± 1.66) d, (8.42 ± 1.49) d of the control group (P<0.05). The total efficiency rate in the observation group was 97.56%, which was significantly higher than 85.37% of the control group (P<0.05). After treatment, the serum CRP, TNF-αand IL-6 in both groups were significantly reduced, and those in observation group were significantly better than the control group (P<0.05). Conclusion Xiaoer-feire-kechuan oral solution can inhibit the inflammatory response, ad-just the immune balance to quickly relieve clinical symptoms, and shorten the course and improve the clinical efficacy in thetreatment of children with Mycoplasma pneumoniae infection.%目的 观察小儿肺热咳喘口服液佐治支原体肺炎的疗效,并探讨其对患儿血清炎症因子的影响.方法 选择2014年6月至2016年2月我院儿科收治的82例支原体肺炎患儿为研究对象,根据随机数表法随机分为对照组和观察组,每组41例.对照组患儿予常规阿奇霉素治疗,观察组患儿则联合应用小儿肺热咳喘口服液治疗,疗程均为7 d.比较两组患儿的临床疗效,以及治疗前后的血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平.结果 观察组患儿的退热时间、肺部啰音消失时间、住院时间分别为(2.56±0.69)d、(5.83±0.77)d、(7.69±1.00)d,均明显短于对照组的(3.59±1.24)d、(6.86±1.66)d、(8.42±1.49)d,差异均有统计学意义(P<0.05);观察组患儿的治疗总有效率为97.56%,明显高于对照组的85.37%,差异有统计学意义(P<0.05);两组患儿治疗后的CRP、TNF-α及IL-6水平较治疗前显著降低,且上述指标观察组降低明显优于对照组,差异均有统计学意义(P<0.05).结论 小儿肺热咳喘口服液佐治小儿支原体肺炎可通过抑制炎症反应、调节免疫平衡快速缓解临床症状、缩短病程,提高临床疗效.