Objective To investigate the changes and clinical significance of serum vascular endothelial growth factor (VEGE) levels in patients with acute ST segment elevation myocardial infarction before and after percuta-neous coronary intervention (PCI). Methods A total of 98 patients with acute ST segment elevation myocardial infarc-tion, who admitted to the Fifth Affiliated Hospital of Zunyi Medical College (Zhuhai) from Jan. 2016 to Apr. 2017, were selected as the observation group. Meantime, 50 healthy people undergoing physical examination were chosen as the con-trol group. The clinical data of the two groups were compared, and the preoperative and postoperative VEGF levels of the two groups before and after PCI were observed and compared. Results The proportion of hypertension, diabetes and smoking history in the observation group were 54.1%, 29.6%and 55.1%, respectively, which were significantly high-er than corresponding 24.0%, 18.0%and 30.0%in the control group (P<0.05). The incidence of hypertension, diabetes and smoking among restenosis patients were 87.5%, 75.0% and 87.5%, respectively, which were significantly higher than corresponding 51.1%, 25.6%and 52.2%in non-restenosis patients (P<0.05). The preoperative VEGF levels in reste-nosis patients and non-restenosis patients were respectively (428.25 ± 30.15) pg/mL and (412.07 ± 33.64) pg/mL, which were significantly higher than (287.42±38.72) pg/mL in the control group (P<0.01). There was no significant difference in VEGF level between the restenosis patients and non-restenosis patients before operation (P>0.05). The level of VEGF of the restenosis group 3 days and 7 days after PCI were respectively (381.21 ± 40.18) pg/mL and (299.55 ± 34.64) pg/mL, which were significantly lower than corresponding (349.30±34.91) pg/mL and (288.13+39.28) pg/mL of the non-resteno-sis group before the operation (P<0.01);the decrease of VEGF in three days after operation in the restenosis group was sig-nificantly lower than that in the non-restenosis group (P<0.05). Conclusion The decrease of VEGF in patients with acute ST segment elevation myocardial infarction after emergency PCI can be used as the predictor of postoperative restenosis.%目的 观察急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗(PCI)治疗前后血清血管内皮生长因子(VEGE)水平的变化,并探讨其临床意义.方法 选取2016年1月至2017年4月间遵义医学院第五附属(珠海)医院心内科诊治的98例急性ST段抬高心肌梗死患者作为观察组,50例进行体检的健康人作为对照组,比较两组受检者的基本资料,观察患者PCI术前和术后VEGF水平变化特征及临床意义.结果 观察组患者的高血压、糖尿病、吸烟史所占比例分别为54.1%、29.6%和55.1%,均明显高于对照组的24.0%、18.0%和30.0%,差异均有统计学意义(P<0.05);其中出现再狭窄患者高血压、糖尿病、吸烟史患者所占比例分别为87.5%、75.0%和87.5%,均明显高于未出现再狭窄患者的51.1%、25.6%和52.2%,差异均有统计学意义(P<0.05);再狭窄患者和无再狭窄患者术前VEGF水平分别为(428.25±30.15)pg/mL和(412.07±33.64)pg/mL,明显高于对照组的(287.42±38.72)pg/mL,差异均有统计学意义(P<0.01),而再狭窄患者和无再狭窄患者术前VEGF水平比较差异无统计学意义(P>0.05);再狭窄组患者术后3 d和7 d VEGF水平分别为(381.21±40.18)pg/mL和(299.55±34.64)pg/mL,无再狭窄组患者分别为(349.30±34.91)pg/mL和(288.13±39.28)pg/mL,均显著低于同组术前,差异均有显著统计学意义(P<0.01);再狭窄患者术后3 d VEGF下降程度明显低于无再狭窄患者,差异有统计学意义(P<0.05).结论 急性ST段抬高型心肌梗死患者急诊PCI术后VEGF下降幅度可以作为患者术后再狭窄预测指标.
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