Objective To investigate the clinical effect of intratympanic methylprednisolone in the treatment of refractory sudden deafness. Methods A total of 34 patients with refractory sudden deafness were enrolled from January 2013 to June 2016 in the Department of Otolaryngology in Shajing People's Hospital of Bao'an District of Shenzhen City. Sixteen patients who were treated with conventional therapy were included into the control group, and 18 patients who received intratympanic methylprednisolone were treated in the observation group for 8 days. Pure tone average (PTA) of the air conduction threshold was compared between the two groups before and after treatment, and medica-tion safety of the observation group was observed. Results After treatment, the PTA in the observation group was (52.36±6.43) dB, which was significantly lower than (63.15±7.82) dB in the control group (P<0.05). The effective rate of treatment in the observation group was 44.4％, which was significantly higher than that in the control group (6.3％), P<0.05. In the observation group, only one patient had dizziness during the injection and no serious adverse reactions. Conclusion Intratympanic methylprednisolone is an effective and safe treatment for refractory sudden deafness.%目的 探讨鼓室内注射甲强龙治疗难治性突发性耳聋的临床疗效.方法 选择2013年1月至2016年6月期间深圳市宝安区沙井人民医院耳鼻喉科收治的34例难治性突发性耳聋患者为研究对象,将继续常规治疗的16例患者纳入对照组,18例接受鼓室内注射甲强龙治疗的患者纳入观察组,疗程8 d.比较两组患者治疗前后的气导纯音听阈均值(PTA)以及观察组的用药安全性.结果 治疗后观察组患者的PTA为(52.36±6.43)dB,明显低于对照组的(63.15±7.82)dB,差异有统计学意义(P<0.05);观察组患者的治疗有效率为44.4％,明显高于对照组的6.3％,差异有统计学意义(P<0.05);观察组仅1例患者注射过程中出现眩晕,无严重不良反应.结论 鼓室内注射甲强龙是治疗难治性突聋有效、安全的一种治疗方案.
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