红背山麻杆叶的化学成分研究（Ⅲ）-奎宁酸类化合物

摘要

Alchornea trewioides is a kind of Traditional Chinese Medicine,which was used to treat prostate gland,shi-gella,lumbocrural pain,inflammation and other diseases in China,and its chemical constituents and antioxidation ac-tivity have been reported.To continue invested the chemical composition and master the material basis of A. trewioides,80% acetone extracts of the fresh leaves of A.trewioides was successively separated by Sephadex LH-20,MCI gel CHP 20P,and Toyopearl Butyl-650C column chromatography to yield five quinic acids.Their structures were elucidated spectroscopic analyses as:3-O-caffeoylquinic acid(1),4-O-caffeoylquinic acid(2),5-O-caffeoylquinic acid(3),4-O-galloylquinic acid (4),and 5-O-galloylquinic acid(5).Compounds 1-5 were isolated from the Alchornea for the first time.Oxygen radical absorbance capacity (ORAC)of the all compounds were also compared and com-pounds 1-5 were observed to show the strongest antioxidation activity.%红背山麻杆作为一种常用的传统中药材，它常常被用来治疗前列腺、腰腿痛、炎症等疾病，它的化学成分及抗氧化活性已有研究报道。为了继续研究红背山麻杆的化学成分，以掌握其物质基础，对新鲜叶子80％丙酮提取物水萃取部位，利用凝胶、MCI及Toyopearl Butyl-650C柱色谱进行分离、纯化得到5个奎宁酸类化合物。根据化合物的波谱数据分析鉴定为3-O-咖啡酰基奎宁酸(1)、4-O-咖啡酰基奎宁酸(2)、5-O-咖啡酰基奎宁酸(3)、4-O-galloylquinic acid(4)、5-O-galloylquinic acid(5)。化合物1~5均为首次从本属植物中分离得到。通过抗氧化能力指数检测(ORAC法)，所有的化合物均表现出较强的抗氧化活性。