外周血中PIPmRNA的表达及在乳腺癌微转移中的临床意义

摘要

Objective To assess the prognosis values of prolactin-induced protein(PIP) mRNA in breast carcinoma and tumor micrometastasis. Methods Peripheral serum samples of 75 patients with breast carcinoma, 21 patients with benign breast lesions and 20 controls were collected, PIP mRNA was assessed by RT-PCR. Results The positive rate of PIPmRNA in breast carcinoma patients, benign breast lesions and controls group was 30.7%, 0%and 0%. Signiifcant differences were found in the expression of PIPmRNA in peripheral serum among patients with control groups, benign breast lesions patients with breast carcinoma (P<0.05). The positive rates and related of PIPmRNA was signiifcantly correlated with clinical stage (P<0.05). There were no signiifcant differences among any of age,histopathology types,estrogen receptor and progesterone receptor(P>0.05). Conclusion Breast carcinoma and tumor micrometastasis patients with positive PIP mRNA was a close relationship.%目的：探讨泌乳素诱导蛋白( PIP) mRNA对乳腺癌微转移的临床价值。方法采用逆转录-多聚酶链反应（RT-PCR）技术检测75例乳腺癌患者、21例乳腺良性病变患者和20例健康者外周血中PIPmRNA的表达情况。结果75例乳腺癌患者外周血中PIP mRNA有23例表达，阳性率为30.7%，乳腺良性肿瘤组和对照组中PIP mRNA表达为阴性。两组比较差异有显著性（P＜0.05）。PIPmRNA阳性表达与患者的淋巴结转移状况、原发肿瘤大小、分期显著相关（P＜0.05）；而与患者的年龄、病理类型、ER、PR等无显著相关（P＞0.05）。结论外周血PIP mRNA阳性表达与乳腺癌微转移有关。