高区域选择性合成3-（芳胺）-N，N -二甲基丙酰胺衍生物

摘要

The highly regioselective intermolecular addition for the synthesis of 3 -( arylamino ) -N, N -dimethylpropanamide derivatives from aromatic amines and N , N -dimethylacrylamide in the presence of hydrochloride ( HCl) was introduced.The structures of product were confirmed by 1 H -NMR, 13 C -NMR and melting point.The results showed that this synthetic route had the advantages of easy -obtained raw materials , atom economy , simple work-up and high purity product , therefore, this strategy provided a alternative method for the high efficient , rapid synthesis of 3-( arylamino )-N,N-dimethylpropanamides.%以N，N-二甲基丙烯酰胺和芳胺类化合物为原料，盐酸为促进体系，经过分子间的高区域选择性加成，成功地构建出了3-（芳胺）-N，N-二甲基丙酰胺衍生物。采用1 H-NMR、13 C-NMR和熔点对目标产物进行了表征。研究表明该方法具有原料便宜易得、原子经济、后处理操作简单和产品纯度高等优点，为3-（芳胺）-N，N-二甲基丙酰胺衍生物的高效、快速合成提供了一条可选的策略。