超声造影对甲状腺肿瘤诊断价值的Meta分析

摘要

Objective To evaluate Meta-analysis in assessing the diagnostic value of contrast-enhanced ultrasound ( CEUS ) in patients with thyroid neoplasms. Methods A comprehensive search was done in Cochrane library, Pubmed database, Embase, CBM and Wanfang database. All the literatures about the diagnosis of thyroid cancer with CEUS were in the retrieval, and data of relevant literatures were extracted. According to the diagnostic test criteria recommended by Cochrane Screening and Diagnostic Test Group, the relevant literatures were screened, an evaluation on their quality was done, and feature informations were extracted for the study. To conduct Meta-analysis and paint summary receiver operating characteristic( SROC ). Results Five selected literatures had homogeneity nature, using two-variable fixed-effects model. The pooled sensitivity and specificity were 89%( CI:0.81 -0.94 ) and 89%( CI:0.81 -0.94 ), respectively,while the pooled positive and negative likelihood ratio were 7.98( CI:4. 71 -13.51 ) and 0.12( CI:0. 07 -0.21 ), respectively. The area which was under the curve of the summary receiver operating characteristic( SROC ) was 0. 89, SE =0. 02. Conclusion Meta-analysis and SROC curve suggest that CEUS is of great value in the diagnosis of thyroid neoplasm.%目的 用Meta分析方法评价超声造影(CEUS)对甲状腺肿瘤诊断的价值.方法 搜索Cochrane library、Pubmed数据库、Embase数据库、CBM以及万方数据库,检索所有用超声造影对甲状腺肿瘤进行诊断的文献,提取相关文献数据.根据Cochrane协作网筛选与诊断试验方法组推荐的诊断试验纳入标准筛选文献,对文献进行质量评价,并提取纳入研究的特征信息,进行Meta分析,绘制受试者工作特征曲线(SROC).结果 共纳入的5篇文献具有同质性,利用双变量固定效应模型,合并诊断敏感度和特异度分别为89%(CI:0.81～0.94)、89%(CI:0.81～0.94),合并阳性和阴性似然比分别为7.98(CI:4.71～13.51)、0.12(CI:0.07～0.21),SROC曲线下面积为0.89,SE=0.02.结论 Meta分析及SROC曲线提示,CEUS对甲状腺肿瘤具有较高临床诊断价值.