2324例门诊患者人乳头瘤病毒感染状况及亚型分析

摘要

Objective To investigate the distribution and major subtypes of human papillomavirus ( HPV ) infection,and to provide a basis for clinical treatment .Methods The detection of HPV was performed in 2 324 outpatients. Results Among 2 324 cases,1 528 cases of HPV positive accounted for 65.7%,with 1 314 females(56.5%) and 214 males (9.2%).In females,the patients aged 30-39 years old showed the highest infection rate (86.2%,467/542),which was significantly higher than those in the other groups (P<0.01).In males,the patients aged 20-29 years old showed the highest infection rate(54.9%,96/175),which was significantly higher than those in the other groups (P<0.01).The single infection was most common in both females and males ,50.5%(895/1 772) and 32.6%(180/552),respectively.The types of HPV35 and HPV43 were not detected.In females, the top 4 high-risk types were HPV16 (26.9%), HPV52 (15.6%),HPV58(8.5%) and HPV53(5.0%),respectively,while low-risk types were HPV11(8.0%) and HPV6 (6.5%).The most common types in males were HPV11(40.5%)and HPV6(32.0%).Significant gender difference was observed in the infection rate between high-risk types and low-risk types.Conclusion The HPV infection is sensitive in the particular age ,as for 30-39 years old in females while 20-29 years old in males .The types of infection are dominated by single infection ,and gender difference can be found in the distribution of HPV subtypes infection .%目的：观察人乳头瘤病毒（ HPV）感染状况并对病毒亚型进行分析，为临床提供诊疗依据。方法对2324例门诊患者进行HPV检测。结果2324例受检者中HPV阳性1528例（65．7％），其中女1314例（56．5％），男214例（9．2％）。女性患者中30～39岁组HPV阳性率最高，达86．2％（467/542），与其他组比较，差异有统计学意义（P＜0．01）；男性以20～29岁组HPV阳性率最高，占54．9％（96/175），与其他组比较，差异有统计学意义（ P＜0．01）。女性与男性均以单一感染为主，分别为50．5％（895/1772）及32．6％（180/552）。HPV的35和43亚型未检出。女性患者高危亚型前4位依次为HPV16（26．9％）、HPV52（15．6％）、HPV58（8．5％）和HPV53（5．0％）；低危亚型以HPV11（8．0％）、HPV6（6．5％）多见。男性感染以低危亚型为主，以HPV11（40．5％）、HPV6（32．0％）多见。高危亚型与低危亚型感染存在性别差异。结论 HPV感染易高发于某一特定的年龄段，女性以30～39岁为主，男性以20～29岁为主，感染类型均以单一感染为主，人群的HPV感染亚型分布具有性别差异。