新生儿呼吸窘迫综合征患儿血清转化生长因子-β1、骨形态发生蛋白-7、维生素A水平及其与病情程度的关系

摘要

Objective To investigate the expressions of serum transforming growth factor beta 1 ( TGF-β1 ) , bone morphogenetic protein-7(BMP-7) and vitamin A in infants with neonatal respiratory distress syndrome (NRDS) and their relationship with the severity of disease.Methods Sixty-four infants with NRDS and 60 preterm infants without NRDS were enrolled as NRDS group and control group respectively .The levels of TGF-β1 ,BMP-7 and vitamin A were detected in both groups .Results Serum TGF-β1 and BMP-7 levels in the NRDS group were higher than the levels in the control group (P<0.05),but there was no significant difference in serum vitamin A level between the two groups(P>0.05).The serum TGF-β1 and BMP-7 levels in the infants with grade Ⅲ-ⅣNRDS were higher than those in the infants with grade Ⅰ-Ⅱ(P<0.05).In the infants with NRDS,serum TGF-β1 and BMP-7 levels positively correlated with the severity of disease(P<0.05),but serum vitamin A level did not correlate with the severity of disease (P>0.05).Conclusion Serum TGF-β1 and BMP-7 levels increase significantly in the infants with NRDS ,and the disease is more severer when the levels are higher .%目的 探讨血清中转化生长因子-β1(TGF-β1)、骨形态发生蛋白-7(BMP-7)、维生素A在新生儿呼吸窘迫综合征(NRDS)患儿中的表达情况及其与病情程度的关系.方法 选取64例NRDS患儿及60例无NRDS的早产儿分别作为NRDS组、对照组,检测两组TGF-β1、BMP-7和维生素A水平.结果 NRDS组血清TGF-β1和BMP-7水平高于对照组(P<0.05),两组血清维生素A水平差异无统计学意义(P>0.05);病情Ⅲ~Ⅳ级NRDS患儿血清TGF-β1和BMP-7水平高于Ⅰ~Ⅱ级患儿(P<0.05);NRDS患儿血清TGF-β1和BMP-7水平与病情程度呈正相关(P<0.05),但维生素A与病情程度无相关性(P>0.05).结论 NRDS患儿血清TGF-β1和BMP-7水平明显升高,且两者水平越高患儿病情程度越重.