痹祺胶囊治疗肝肾亏虚型膝关节炎的临床效果观察

摘要

目的 观察痹祺胶囊治疗肝肾亏虚型膝关节炎的临床疗效.方法 原发性膝关节炎患者124例,中医辨证分型均为肝肾亏虚型.将其随机分为对照组和观察组,每组62例,对照组给予塞来昔布治疗,观察组在对照组的基础上给予痹祺胶囊治疗,均连续治疗12周.比较两组的临床疗效,疼痛、肿胀、压痛及功能障碍评分,以及美国特种外科医院(HSS)评分.结果 治疗后,观察组治疗总有效率高于对照组(91.94%比74.19%,P<0.05),疼痛、肿胀、压痛及功能障碍评分均低于对照组(P<0.05),HSS评分高于对照组(P<0.05).结论 联合使用痹祺胶囊可有效改善肝肾亏虚型骨性关节炎患者的疼痛、肿胀及功能障碍等临床症状,疗效优于单纯口服塞来昔布.%Objective To observe the clinical efficacy of Biqi capsule on osteoarthritis of hepatic and renal deficiency type.Methods A Total of 124 patients with primary osteoarthritis were classified as hepatic and renal deficiency type by traditional Chinese medical syndrome differentiation.All of the patients were randomized into control group or observation group,with 62 cases in each group.The control group was treated with celecoxib,while the observation group was given Biqi capsule on the basis of therapy performed in the control group.The treatment lasted for 12 weeks.The clinical efficacy,pain,swelling,tenderness and dysfunction scores,and the Hospital for Special Surgery(HSS) score were compared between the two groups.Results After treatment,the total effective rate in the observation group was higher than that in the control group(91.94% vs.74.19%;P<0.05).Pain,swelling,tenderness and dysfunction scores were lower while HSS score was higher in the observation group compared to the control group(P<0.05).Conclusion A combined therapy with Biqi capsule can effectively improve the clinical symptoms of pain,swelling and dysfunction in patients with osteoarthritis of hepatic and renal deficiency type,which had a better efficacy compared to oral celecoxib alone.