酒精性肝病患者血清腺苷脱氨酶活性的研究

摘要

目的：本实验是为了研究酒精性肝病患者腺苷脱氨酶活性，建立一种早期预警酒精性肝病严重程度的方法。方法60例酒精性肝病患者被分为3组，（脂肪肝20例、酒精性肝炎22例、酒精性肝硬化18例）；对照组健康男性60例，同时测定腺苷脱氨酶活性、肝功能参数。结果酒精性肝病患者腺苷脱氨酶均显著高于对照组，酒精性肝炎和肝硬化组腺苷脱氨酶均显著高于脂肪肝组和对照组。结论本研究显示增高的腺苷脱氨酶、AST、ALT、GGT提示肝细胞的破坏，酒精性肝病患者血清腺苷脱氨酶检测是一种无创性的检查，很容易在基层医院推广，有助于早期疾病诊断，在疾病发展到严重阶段之前进行诊治和行为干预。%Objective The present study was designed to evaluate adenosine deaminase activity levels in patients with alcoholic liver disease to establish the method to monitor the severity of this disease.Methods 60 cases of patients with alcohol liver disease were divided into three groups ( there was 20 cases of patients with fatty liver, 22 cases of patients with alcoholic hepatitis and 18 cases of patients with cirrhosis and control group of 60 healthy males were enrolled in the study.Adenosine deaminase and liver function test parameters of the two groups were analyzed.Results Adenosine deaminase of the patients with alcohol liver disease was significantly higher than that of the control groups.Adenosine deaminase of patients with alcoholic hepatitis and patients with cirrhosis were significantly higher than that of the fatty liver group and the control group.Conclusions The present study demonstrated the increased adenosine deaminase, AST, ALT and GGT indicated live cells were damaged.The estimation of serum adenosine deaminase level in the patients of alcoholic liver disease was an important non invasive prognostic tool which may be widely used in primary hospitals and may be helpful in the treatment and behavior interventions before the diseases develop the severe stages.