乳腺癌术前灰阶超声与彩色多普勒超声联合应用对预后的预测价值

摘要

目的：探究乳腺癌术前灰阶超声与彩色多普勒超声联合应用对预后的预测价值。方法选取温州医科大学附属第一医院2013年5月—2015年5月期间收治的乳腺癌患者83例,治疗前均行灰阶超声与彩色多普勒超声检查,分析患者超声检查结果、临床征象与术后随访2年期间患者预后的关系,从而分析术前灰阶超声与彩色多普勒超声联合应用对乳腺癌患者预后的预测价值。结果乳腺癌肿块边界清晰、边界不清晰、边界恶性晕的患者2年无瘤生存率依次降低,边界恶性晕与边界不清晰患者死亡率均显著高于边界清晰患者( P<0．05)；肿瘤≥2 cm患者2年无瘤生存率显著低于<2 cm患者；淋巴结转移患者2年无瘤生存率显著低于无转移患者(P<0．05)；血流分级Ⅱ级患者2年无瘤生存率明显低于0级(P<0．05),Ⅲ级患者2年无瘤生存率显著低于0级和Ⅰ级(P<0．05)。结论乳腺癌患者术前联合应用灰阶超声与彩色多普勒超声检查可确定肿瘤边界、大小及淋巴转移等征象,其与患者无瘤生存率、死亡率等预后指标密切相关,可作为预测乳腺癌患者预后的重要方法。%Objective To investigate the value of preoperative gray -scale ultrasound combined with color Doppler ultrasound in predicting the prognosis of mammary cancer. Methods 83 cases of patients with breast cancer admitted in our hospital from May 2013 to May 2015 were given gray-scale ultrasound and color Doppler ultrasound examination before treatment. The relationship between the results of ultrasound examination, clinical signs and prognosis of patients in postoperative 2 years of follow-up was analyzed. Thus, the value of preoperative gray-scale ultrasound combined with color Doppler ultrasound in predicting the prognosis of patients with breast cancer was analyzed. Results The 2-year disease-free survival rates of patients with breast masses and clear boundaries, with breast masses and unclear boundaries and with breast masses and boundaries with malignant halo decreased systematically; The mortality rates of patients with breast masses and boundaries with malignant halo and unclear boundaries were significantly higher than patients with clear boundaries ( P <0. 05 ); The 2 -year survival rate of patients with tumors≥2 cm was significantly lower than patients with tumors<2 cm;The 2 year survival rate of patients with lymph node metastasis was significantly lower than patients without metastases; The 2 year survival rate of patients with Ⅱgrade blood flow was significantly lower than patients with 0 grade blood flow; The 2 year survival rate of patients with Ⅲ grade blood flow was significantly lower than patients with 0 grade and Ⅰgrade blood flow ( P <0. 05 ) . Conclusion The gray scale ultrasound combined with color doppler ultrasound can determine tumor boundary tumor size and lymph node metastasis in mammary cancer before operation, the clinical sign has a tight correlation with tumor free survival rate and mortality. It can be used as an important method to predict the prognosis of mammary cancer.