目的 分析并研究早期多药联合干预对早产儿脑白质软化的治疗效果.方法 将珠海市妇幼保健院收治的早产儿脑白质软化患儿68例作为研究对象,随机将患儿分为两组,每组各34例,其中对对照组患儿实施常规治疗方式,给予观察组患儿在常规治疗的基础上实施早期多药(神经节苷脂、1,6-二磷酸果糖和鼠神经生长因子)联合干预治疗,同时分别给予两组患儿脑白质损伤程度比较,并于患儿1岁时进行智力发育指数和心理运动发育指数的评价比较.结果 观察组患儿脑白质损伤轻度显著高于对照组患儿,脑白质损伤重度显著低于对照组患儿,数据比较差异具有统计学意义(P<0.05);观察组患儿智力发育指数与心理运动发育指数均显著高于对照组患儿,数据比较差异具有统计学意义(P<0.05).结论 对早产儿脑白质软化患儿采用神经节苷脂、1,6-二磷酸果糖和鼠神经生长因子等多药早期治疗能够明显缓解患儿脑白质软化持续性病变的发展,治疗效果显著.%Objective To analyze and study the early multi drug combination intervention on premature Leukoencephalomalacia treatment.Methods Children with periventricular leukomalacia in preterm infants in our hospital 68 cases as the object of study, children were randomly divided into two groups, 34 cases in each group, the control group received routine treatment, observation group were given on the basis of routine treatment, early implementation of multi drug (ganglioside 1,6-two phosphate fructose and mouse nerve growth factor) combined with intervention therapy were given at the same time were compared between the two groups of cerebral white matter damage in children at the age of 1, and intelligence development index evaluation and psychomotor development index comparison.Results Nild observation was significantly higher than the control group in children with white matter brain injury group, severe cerebral white matter damage was significantly lower than the control group, with statistically significant data difference (P<0.05);the observation group with mental development index and psychomotor development index were significantly higher than those in the control group, with statistical significance of data comparison the difference (P<0.05).Conclusion The premature Leukoencephalomalacia were treated with ganglioside 1,6-two phosphate fructose and mouse nerve growth factor and multi drug treatment can significantly alleviate the early development of children with periventricular leukomalacia persistent lesions, the treatment effect is remarkable.
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