Objective To compare ihe efficacy of double - fillralion plasmapheresis (DFPP) and plasma absorp-tion (PA) in the Lreatment of autoimmune diseases. Methods Thirty palienls with autoimmune diseases were divided in-Lo Lwo groups, in which they were trealed wilh DFPP and PA respectively. The serum IgA, IgG, IgM, C3 and C4 levels and blood purification associated complications were compared. Results The reduclion of IgA, IgG, IgM, C3 and C4 af-ter DFPP were (44. 2 ± 14. 0)% , (45.2 ±6.3)%, (49.3 ±13.1)%, (46. 2 ±10.3)% and (44. 0 ± 11. 6)% , re-speclively; and were (42.4 ±8. 5)%, (42.9 ±6.2)%, (46. 1 ±7.2)%, (42.5 ±6.5)% and (48. 3 ±9. 6) %, re-speclively after PA. There was no significant difference in the clearance rales of IgA, IgG, IgM, C3 or C4 between DFPP and PA wilh same dosage. However, significantly lower incidence of blood purification associaled complicalions was revealed in PA trealmenl than DFPP ( P < 0. 05). Conclusion It is suggested that DFPP and PA can effectively remove serum immunoglobulins and complements in treating auloimmune diseases, wilh equal clearance rales, but PA trealment guarantees lower incidence of blood purification associaled complicalions.%目的 比较双重血浆置换(DFPP)和血浆吸附(PA)两种血浆净化方式治疗自身免疫性疾病的差异.方法 30例自身免疫性疾病患者分为两组,分别采用DFPP和PA进行治疗,对单次治疗前后IgA、IgG、IgM、C3、C4指标及血液净化相关并发症情况进行比较.结果 单次DFPP治疗后血清IgA、IgG、IgM、C3、C4水平下降比率分别为(44.2±14.0)%、(45.2±6.3)%、(49.3±13.1)%、(46.2±10.3)%、(44.0±11.6)%,单次PA治疗后血清IgA、IgG、IgM、C3、C4水平下降比率分别为(42.4±8.5)%、(42.9±6.2)%、(46.1±7.2)%、(42.5±6.5)%、(48.3±9.6)%;单次DFPP与PA在相同治疗量下对血清IgA、IgG、IgM、C3、C4的清除效果差异无统计学意义,但PA的血液净化相关并发症发生率比DFPP更低(P<0.05).结论 自身免疫性疾病行DFPP及PA治疗均可以有效地清除血清免疫球蛋白和补体且两者清除效果相当,但PA治疗的并发症发生率更低.
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