红细胞负载盐酸阿霉素给药系统的体外释放特性考察

摘要

Objective To study the in-vitro release behavior of DOX-loaded erythrocyte delivery system.Methods Dialysis method was used to evaluate the in-vitro release properties in PBS. Accumulative DOX release ammount at given time point was measured and various maths models were used to fit the release curve. Results Compared with DOX injection,erythrocyte delivery system could significantly prolong DOX in-vitro release time up to 48 h, and was in line with Ritger-Peppas release model(Qt=25.58t0.36),R2=0.9678).Conclusion Drug loaded erythrocyte delivery system could sustainedly release DOX in vitro.%目的 对红细胞负载盐酸阿霉素(DOX)给药系统的体外释药行为进行研究.方法采用透析法考察载药系统在PBS缓冲液中不同时间的累积释放量并绘制时间关系曲线图,并采用零级、一级,Higuchi以及Ritger-Peppas动力学方程对其体外释放行为进行拟合.结果 体外药物释放结果表明,与游离药物相比,载药红细胞可有效延长释药时间至48 h,且其体外释药行为较符合Ritger-Peppas方程(Qt=25.58t0.36),R2=0.9678).结论红细胞药物载体系统可有效延长药物的释放水平.