目的：从抗炎消肿、镇痛及促溃疡面愈合三个方面，对痔疮消炎膏进行药效学评价，为痔疮消炎膏的临床评价提供实验依据。方法观察痔疮消炎膏高、中、低剂量对二甲苯致小鼠耳廓肿胀的抗炎消肿作用、对小鼠痛阈的影响、对冰醋酸致大鼠肛门溃疡面愈合的影响。结果痔疮消炎膏高、中二个剂量均能明显抑制二甲苯所致的耳部炎症反应，而且其高剂量组的抑制作用优于马应龙麝香痔疮膏；局部涂药高、中、低浓度均可明显提高小鼠热板法致痛的痛阈值而产生较强的镇痛作用；对冰醋酸造模所致肛门溃疡的大鼠，高浓度组可以明显促进小鼠皮肤溃疡的愈合，缩小皮肤溃疡面积。结论痔疮消炎膏具有明显的抗炎消肿、镇痛、促进溃疡面愈合的功效，是外治法治疗痔疮的优良的外用药。%Objective To evaluate the efficacy of hemorrhoids anti-inflammatory ointment on the basis of the anti-inflammation, analgesia and ulcer healing promoting , and to provide experimental basis for clinical evaluation for hemorrhoids anti-inflammatory ointment .Methods To observe the hemorrhoids anti-inflammatory cream, in high, middle,low dose on xylene induced mouse auricle swelling effect , hot plate method for mice analgesia experiment effect on the pain threshold of mice , injection of acetic acid induced rat anal ulcer surface healing .Results Hemorrhoids Anti-inflammatory Ointment , in high, middle dose on xylene induced mouse auricle swelling effect significantly inhibited the mice ear edema .The inhibitory effect of high dose group was better than Mayinglong Musk Hemorrhoids Ointment .And the three group of mice hot-plate procedures all can remarkably increasesd mice pain threshold .The high dose group can im-prove to heal the ulcer skin of mice obviously and to reduce the area of ulcer about the Glacial acetic acid lead to anal ulcer in rats .Conclusion The Hemorrhoids Anti-inflammatory Ointment has strong effects of anti-inflammation , analgesia , and improving heal to ulcer .It is a good drug to treat hemorrhoids with exter-nal treatment .
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