中医药对骨关节炎动物模型细胞因子作用研究进展

摘要

Osteoarthritis is a chronic disease, which mainly results from the articular cartilage damage of intergrity and articular cartilage under plate of bone lesions. At present, the pathogenesis of os-teoarthritis is still not clear. Cytokines may be involved in the pathogenesis through a complex mechanism. Traditional Chinese medicine has unique advantages in improving the symptoms and signs of patients with osteoarthritis. This paper reviewed the effects of cytokines in the animal model of osteoarthritis treated by Traditional Chinese medicine in recent years. It is reviewed that Traditional Chinese medicine can protect the articular cartilage, slow down osteoarthritis osteophyte formation and postpone the process of osteoarthritis by inhibiting the formation of IL( Iinterleukin) , reducing the level of TNF-α( tumour necrosis factor-α) in serum and synovial fluid, increasing TGF- β( transforming growth factor-β) expression and raising the level of it, decreasing CTGF ( connective tissue growth factor ) expression to slow down the formation of osteophyte and the progression.%骨关节炎以关节软骨及软骨下骨受累为主,目前发病机制尚不明确,细胞因子可能通过复杂的作用机制参与骨关节炎的形成。中医药能有效改善骨关节炎患者的症状及体征,具有独特优势。本文从细胞因子作用研究方面,通过对近年来中医药治疗骨关节炎动物模型的文献进行综述总结,认为中医药能够抑制白细胞介素( interleukin,IL)的形成,降低血清和关节液中肿瘤坏死因子-α( tumor necrosis factor-α,TNF-α)的水平,上调转化生长因子( transforming growth factor-β,TGF-β)的表达,提高TGF-β的水平,下调结缔组织生长因子( connective tissue growth factor,CTGF)的表达以降低CTGF介导的软骨细胞的增殖与表达,达到保护关节软骨,减缓骨关节炎骨赘的形成,减缓发病进程的目的。