基于“肾藏精,在志应恐”理论的创伤后应激障碍病机与防治研究思路探讨

摘要

运用中医药理论和治法方药防治创伤后应激障碍( post-traumatic stress disorder, PTSD)的研究虽然刚刚起步,但已显示出良好的应用前景。本文立足于中医“肾藏精,在志应恐”的理论,剖析PTSD的中医病因病机,认为“肾精不足,封藏失职,志气衰败”是PTSD中医病机核心之所在。此外,本文对中医补肾治法方药防治PTSD的现状与药理学基础进行了分析和探讨；同时,从临床研究、动物模型以及药理学机制研究等方面提出了今后运用补肾治法方药防治PTSD的研究思路。%Although researches on using traditional Chinese medicine theory and formulae in treating and preventing post-traumatic stress disorder ( PTSD) has just started, but it has shown a good ap-plication prospect. Based on the theory of “kidney stores essence and responses to fear” in traditional Chinese medicine, in this paper, the pathology of post-traumatic stress disorder ( PTSD) was analyzed, and showed that the core pathology was“the deficiency of kidney essence, dysfunction in essence storage, which leads to the decline of will”. In addition, the current situation and pharmacological mechanism of“invigorating the kidney” treatment for PTSD were discussed and analyzed, meanwhile, research ideas were proposed from the aspects of clinical research, animal models and pharmacological mechanism and so on.