Objective To optimize the extraction pzocess of the total alkaloids in the bulbs of FnitiUaria ussuriensis Maxim,analyze the changes of the total alkaloidthe in the different processed products. Methods Based on the results of others, orthogonal test was used in optimizing the extraction process of the total alkaloids; traditional processing methods （vinegar, wine, ginger, honey） were used in the new product development. Results 75% aclcohol and two time extraction could take a better recover in the total alkaloid content; and the total alkaloid contents are as the followings： 0.191% in the products with traditional methods, 0.242%, 0.204%, 0.186%. 0.167% with vinegar, wine, ginger, honey respectively. Conclusion The optimal extraction techniqaes for the total alkaloids from the bulbs of Fritillaria ussuriensis Maxim ks 75% aclcohol and two time extraction. Vinegar, wine could effectively increase the total alkaloid content, and ginger, honey are opposite.%目的优化平贝母总生物碱提取工艺，分析不同新炮制品的总生物碱变化情况，为其开发利用提供理论依据。方法参考前人的研究成果。采用正交实验法优化平贝母总生物碱提取工艺：采用传统中药的炮制方法（醋炙、酒炙、姜炙、蜜炙）加工平贝母新产品。结果75％乙醇提取2次。每次提取时间2h，总生物碱得率最高；与传统加工品中的总生物碱含量（0．191％）相比，醋炙、酒炙分别为0．242％、0．204％：姜炙、蜜炙分别为0．186％、0．167％。结论平贝母中总生物碱的最佳提取工艺为：75％乙醇提取2次，每次提取时间2h。醋炙、酒炙能有效地提高平贝母的有效成分含量；姜炙、蜜炙则相反。
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