目的 探讨盐酸依托必利对老年冠心病患者QT间期和QT离散度(Qtdispersion,(QTd>的影响,评估其心血管安全性.方法 58例老年冠心病患者,合并功能性消化不良或功能性便秘,服用盐酸依托必利片50 mg/次,3次/d.连续服用7~56d,平均(28.7±12.8)d,服药前后记录12导联心电图,计算QT和QTd值,比较服药前、后二者变化.其中28例患者服药14 d时加量至100 mg/次,3次/d,记录服药前、后和14 d的QT和QTd值,然后进行比较.结果 治疗前、后患者QT和QTd值均无明显变化,药物加量至300 mud对QT和QTd值无影响,结论盐酸依托必利对于老年冠心病患者QT间期和QT离散度无影响,且药物加量至300 mg/d也未见有潜在的心血管危险性.%Objective To investigate the effects of itopride hydrochloride on QT interval and QT dispersion (QTd) in elderly patients with coronary heart disease and to evaluate its cardiovascular safety. Methods 58 cases with coronary heart disease, combining with functional dyspepsia or functional constipation were investigated. The patients were given itopride hydrochloride 50 mg/each time (three times each day) for 7-56 days (averaged 28.7 +12.8 d). 12 lead electro-cardiograms (ECGs) were recorded before and after itopride hydrochloride treatment. QT interval and QTd were measured. The drug was added up to 100 mg/each time (three times each day) in 28 cases still on the 14th day. QT interval and QTd were recorded before treatment and the 14th day after treatment. Results QT interval and QTd had no significant changes after treatment compared with the data before treatment. The drug added up to 300 mg each day had no significant effects on QT interval and QTd. Conclusions Itopride hydrochloride has no effects on QT interval and QT dispersion of elderly patients with coronary heart disease. The drug added up to 300 mg has no potential cardiovascular risk.
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