Objective To investigate the expressions and clinical significance of chemokine SDF-1 and its receptor CXCR4 in elderly patients with epithelial ovarian tumor. Methods 43 cases with epithelial ovarian cancer were studied ran-domly. The expressions of SDF-1 and CXCR4 proteins were detected by Western blotting. Results There were weak ex-pression of SDF-1 and modest expression of CXCR4 in benign ovarian tumor of elderly patients. The expressions of SDF-1 protein and CXCR4 protein were significantly increased in epithelial ovarian cancer, compared with benign ovarian tumor (2.38±0.20 vs 3.32±0.26) (P<0.05). Conclusion SDF-1/CXCR4 may play a role in the malignant transformation of primary ovarian cancer and involve in the initiation, progression and metastasis of ovarian cancer of elderly patients.%目的 探讨趋化因子SDF-1及其受体CXCR4在老年人卜皮性卵巢癌组织中的表达及意义.方法 应用western blotting方法定量检测43例老年患者卜皮性卵巢癌组织中SDF-1和CXCR4的蛋白表达情况.结果 老年人上皮性卵巢癌组织中SDF-1/CXCR4蛋白表达较卵巢良性肿瘤对照组明显增加.其相对表达量分别为(2.38±0.20)和(3.32±0.26),差异具有统计学意义(P<0.05).结论 SDF-1/CXCR4生物学轴可能在老年人卵巢癌的发生与转移过程中起着重要作用.
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