阿司匹林口服致上消化道出血的危险因素分析

摘要

Objective: To investigate the risk factors of upper gastrointestinal bleeding after oral administration of aspirin in patients with upper gastrointestinal bleeding. Methods:Randomly selected patients with 200 patients treated in our hospital from July 2013 -2015 to July,divided into the control group and the experimental group,the symptoms of upper digestive tract bleeding were the control group, and the symptoms of upper gastrointestinal bleeding were the experimental group.Observe the clinical symptoms of the two groups and analyze the risk factors by multivariate linear regression analysis. Results:The incidence of erosive gastritis and gastric ulcer in the experimental group was significantly higher than that in the control group, while the incidence of duodenal and combined ulcer was significantly lower than that in the control group, multivariate linear regression analysis showed that the age of 60 years, suffering from ulcer disease, HP infection and diabetes mellitus were four independent risk factors of upper digestive tract bleeding. Conclusion: Age over 60 years old, suffering from ulcers, diabetes, and HP infection are four major independent risk factors for patients with upper gastrointestinal bleeding after taking aspirin. So patients with these four indicators should be banned from taking aspirin, in order to avoid upper gastrointestinal bleeding and other adverse reactions.%目的：探讨患者口服阿司匹林后出现上消化道出血的危险因素。方法：随机选取2013年7月-2015年7月间在我院接受治疗的200例口服阿司匹林的患者，分为对照组和观察组，其中未出现上消化道出血症状的为对照组，出现上消化道出血症状的为观察组。对两组患者的临床症状进行观察对比，并对危险因素进行多元线性回归分析。结果：观察组糜烂性胃炎以及胃溃疡的发生率均显著高于对照组，而十二指肠和复合溃疡的发生几率则显著低于对照组，经多元线性回归分析显示年龄超过60岁、患有溃疡病史、HP感染、糖尿病是导致上消化道出血的四个独立危险因素。结论：年龄超过60岁、患有溃疡病史、患有糖尿病以及HP感染是导致患者口服阿司匹林后上消化道出血的四种主要的独立危险因素，所以符合这四种指标的患者应禁止服用阿司匹林，以免出现上消化道出血以及其他不良反应。