Analysis of the risk factors of rebleeding after endoscopic therapy in patients with non-variceal upper gastrointestinal bleeding

摘要

Objective: To explore the risk factors of rebleeding after endoscopic therapy in patients withnon-variceal upper gastrointestinal bleeding (NVUGIB). Methods: A total of 254 patientswith NVUGIB who were admitted in our hospital for endoscopic therapy were included in thestudy and divided into the rebleeding group (n=76) and non-bleeding group (n=178) accordingto whether there was rebleeding or not. The general materials and laboratory examinationresults in the two groups were recorded. The single factor and multiple factor logisticregression analysis was used to evaluate the risk factors of rebleeding after endoscopic therapyin patients with NVUGIB. Results: The single factor analysis showed that the comparisonof heart rate after admission 100 times/min, upper gastrointestinal tumor bleeding, gradeⅠa bleeding, initial endoscopic therapy time24 h, bleeding lesion diameter2 cm, singleendoscopic therapy method, amount of bleeding800 mL, sequential PPIs insufficiency, andPT≥17 s between the two groups was statistically significant. The multiple factor logisticregression analysis showed that grade Ⅰa bleeding, malignant tumor bleeding, bleeding lesiondiameter2 cm, single endoscopic therapy method, and sequential PPIs insufficiency weresignificantly positively correlated with the occurrence of rebleeding after endoscopic therapy inpatients with NVUGIB. Conclusions: Grade Ⅰa bleeding, malignant tumor bleeding, bleedinglesion diameter2 cm, sequential PPIs insufficiency, and PT≥17 s are the independent riskfactors for developing rebleeding after endoscopic therapy in patients with NVUGIB.