镇痛药地佐辛的毛细管电泳手性分离研究

摘要

地佐辛作为阿片类镇痛药常用于术后止痛、癌症痛等。目前临床上地佐辛以外消旋体的形式给药。本文以麦芽糊精为手性选择剂，手性离子液体四甲基胺-L-酒石酸盐为添加剂，构建了毛细管电泳手性协同分离体系，并将该体系成功的应用于地佐辛对映体的手性分离。%Dezocine,as one of opioid analgesics,was commonly used for postoperative pain,cancer pain etc.And it was cur⁃rently applied as racemic drug in clinical practice.In this paper,the synergistic system of tetramethylammonium-L-tartaric acid and maltodextrin were established ,which can be successfully applied for the chiral separation of the dezocine with a satisfactory recovery .