红景天苷生物合成的细胞与分子生物学研究进展

摘要

红景天苷因其抗氧化、抗疲劳、延缓衰老等生物学功能成为当今天然产物研究的热门方向。本文综述了红景天苷生物合成途径及途径中的相关酶与基因;利用红景天愈伤组织和细胞培养生产红景天苷的方法,通过遗传转化获得毛状根生产红景天苷等细胞与分子生物学的研究。最后提出细胞工程和基因工程是解决药源缺乏的理想途径之一。%Research into salidroside as a naturally occurring compound is a hot topic nowadays due to its multiple bioactivities such as antioxidant,anti-fatigue,and anti-aging functions.This review covers the following aspects of the cellular and molecular biology of salidroside biosynthesis：（1） biosynthesis pathways and related enzymes and genes;（2） salidroside production by Rhodiola rosea callus and cell culture;（3） salidroside production from hair roots obtained by genetic transformation.Therefore,cell engineering and genetic engineering strategies can provide suitable strategies to solve the lack of drug resources.