抗骨质疏松药的研究进展

摘要

Osteoporosis is a systemic skeletal disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to decreased bone strength aud increased bone fracture. Now, three kinds of drags mainly used for the treatment and prevention of ostcoporosis are anti-bone resorption agents, bone formation-promoting agents and the agents with both anti-bone resorption and bone formation-promoting actMties. This paper reviews these drugs and their potential action targets and mechanisms, which will provide some instructions on the development and clinical application of anti-ostcoporosis drugs.%骨质疏松的主要临床表现是骨密度下降,骨微观结构破坏,诱导骨强度下降,微骨折增加.目前主要有3大类药物可治疗和预防骨质疏松症,即抗骨吸收药物、促骨生成药物、抗骨吸收兼具促骨生成药物.现对这3类药物及其潜在的作用靶点、作用机制,以及抗骨质疏松药的开发及临床应用的研究进展作一综述.