炎症因子、脂质水平与2型糖尿病并发冠心病发病风险分析

摘要

Objective To study the correlation between inflammatory factor,lipid levels and the type 2 diabetes mellitus companied with coronary heart disease (CHD). Methods Medical check-up results of our hospital patients and outpatient with di-abetes were analysised from January 2014 to January 2015. There were 58 cases of outpatient medical examination in normal healthy subjects (N) group,56 cases of patients in type 2 diabetes (T2DM) group,64 cases of patients with type 2 diabetes mellitus companied with coronary heart disease (T2DM+CHD) in the third group. And then the inflammatory factor and lipid levels of all the specimens were compared. Results The level of IL-6,HS-CRP and TG,ApoB in T2DM patients were significantly higher than those in healthy controls (P<0.05);and those in T2DM+CHD group were significantly higher than in T2DM group (P<0.05). ApoA1and HDL-C in T2DM and T2DM+CHD were significantly lower than healthy controls(P<0.05),and WBC,TC and LDL-C in T2DM group and T2DM+CHD group were obviously higher than normal controls (P<0.05),while the difference of those between T2DM group and T2DM+CHD group was not statistically significant (P>0.05). Conclusion TC,LDL-C,TG,ApoB,ApoA1,HDL-C,IL-6 and hs-CRP can be used as sensitive markers to provid the basis for early clinical diagnosis and treatment in the develop-ment of T2DM companied with coronary heart disease.%目的：研究炎症因子、脂质水平与2型糖尿病合并冠心病的相关性。方法分析我院2014年1月-2015年1月我院收治的糖尿病患者和同期来我院门诊体检者的体检结果，健康（N）对照组为同期门诊体检者58例，2型糖尿病患者(T2DM)组56例，2型糖尿病合并冠心病患者(T2DM+CHD)组64例，比较三组血清中的炎症因子和脂质水平。结果 T2DM组中血清炎症因子指标（IL-6、HS-CRP）及脂质水平指标（TG、ApoB）水平显著高于健康对照组（P＜0.05），且T2DM合并冠心病组与T2DM组比较水平明显升高（P＜0.05）。 T2DM患者组和T2DM合并冠心病患者组血清中ApoA1、HDL-C较正常体检者偏低（P<0.05），两组比较也具有显著差异（P<0.05）；T2DM组和T2DM合并冠心病组患者的WBC、TC和LDL-C比正常健康组明显升高，差异均有统计学意义（P＜0.05）；但在T2DM组和T2DM合并冠心病组差异均无统计学意义（P＞0.05）。结论T2DM合并冠心病的发展中TC、LDL-C、TG、ApoB、ApoA1、HDL-C、IL-6、HS-CRP可作为较为敏感的指标，为临床早期诊断和治疗提供依据。