托吡酯、卡马西平与丙戊酸钠治疗外伤性癫痫的疗效观察

摘要

OBJECTIVE:To probe into the effects of topiramate , carbamazepine and sodium valproate in treatment of traumatic epilepsy .METHODS: 150 patients with traumatic epilepsy admitted into Guangdong Inductrial Injury Rehabilitation Hospital from Dec .2012 to Feb.2015 were selected to be divided into 3 three groups via the random number table , which were respectively given topiramate , carbamazepine and sodium valproate for treatment .The total effective rate and improvement of life quality score in 3 groups were compared .RESULTS: The total effective rate of topiramate group was 96.00%(48/50), significantly higher than that of carbamazepine group 60.00%(30/50) and sodium valproate group 58.00% ( 29/50 ) , with statistically significant difference ( P<0.05 ) .After treatment , the improvement of life quality score in 3 groups were significantly higher than that of before treatment , and topiramate group was significantly higher than that of carbamazepine group and sodium valproate group , with statistically significant difference ( P <0.05 ) .CONCLUSIONS: The effects of topiramate in treatment of traumatic epilepsy is significant , which can obviously improve the life quality .It is worthy of clinical application and promotion .%目的：探讨托吡酯、卡马西平与丙戊酸钠治疗外伤性癫痫的效果。方法：选取2012年12月—2015年2月广东省工伤康复医院收治的150例外伤性癫痫患者，按随机数字表法分为3组，分别给予托吡酯、卡马西平、丙戊酸钠进行治疗。比较3组患者的总有效率及生活质量评分改善情况。结果：托吡酯组患者的总有效率为96．00％（48／50），明显高于卡马西平组的60．00％（30／50）和丙戊酸钠组的58．00％（29／50），差异有统计学意义（P＜0．05）；治疗后，3组患者的生活质量评分均明显高于治疗前，且托吡酯组明显高于卡马西平组和丙戊酸钠组，差异均有统计学意义（ P＜0．05）。结论：托吡酯治疗外伤性癫痫效果较好，可明显改善患者生活质量，值得临床推广。