OBJECTIVE:To investigate the off-label drug use conditions in pediatric outpatient department of Jingzhou Maternal and Child Health Hospital ( hereinafter referred to as "our hospital") , and to provide reference for the ration drug use in children .METHODS:Prescriptions from pediatric outpatient department of our hospital in 2014 were randomly selected,to judge the medical orders by the drug instruction ,and statistical analysis was conducted on the incidence and types of off-label drug use ,incidence of off-label drug use in children at different age stages and the drugs categories , etc.RESULTS:Of the 1 200 sampled prescriptions , 3 258 cases involved in medical orders , the incidence rate of off-label drug use were 43.83%.The top 3 types of off-label drug use were respectively over optimal application groups ( 53.81%) , over times of administration ( 20.30%) , over dosage of administration ( 13.20%) . Infancy(45.26%),toddler age (45.15%)and preschool age (44.03%)dominated the top 3 places.Meanwhile,the top 3 drugs of off-label drug use were microbe and mineral drugs (55.87%),Chinese patent medicine (50.29%)and anti-infectious agents (46.40%) .CONCLUSIONS:Off-label drug use is a widely existing phenomena ,which needs the clinical physicians to have a good knowledge of drug introductions , and to carry out off-label drug use only with the permission of the patients 'parents;at the same time, the Health Administration should formulate the related management system on off-label drug use ,so as to ensure the safe and effective medication in children .%目的:了解荆州市妇幼保健院(以下简称"我院")儿科门诊超说明书用药现状,为促进儿童安全合理用药提供参考.方法:随机抽取我院2014年门诊儿科处方,根据药品说明书判断医嘱是否超说明书用药,对超说明书用药发生率、超说明书用药类型、各年龄段儿童超说明书用药发生率及药品种类等进行统计分析.结果:在抽取的1 200张门诊儿科处方中,涉及用药医嘱3 258条,超说明书用药发生率达43.83%.超说明书用药类型列前3位的分别是超适用人群(53.81%)、超给药次数(20.30%)、超给药剂量(13.20%);超说明书用药发生率列前3位的分别是婴儿期(45.26%)、幼儿期(45.15%)、学龄前期(44.03%);超说明书用药列前3位的药品分别是微生物与矿物质药(55.87%)、中成药(50.29%)、抗感染药(46.40%).结论:超说明书用药现象普遍存在,临床医师应严格掌握药品的说明书,在权衡利弊并取得患儿家长同意后方可超说明使用药品;同时,卫生行政部门应制订超说明书用药相关管理制度,以保障儿童安全、用药有效.
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