2013-2015年马鞍山市人民医院万古霉素血药浓度监测结果分析

摘要

目的：了解马鞍山市人民医院（以下简称“我院”）2013—2015年度万古霉素血药浓度监测的结果，为临床合理应用万古霉素提供参考。方法：采用酶放大免疫法测定万古霉素的血药浓度，对我院应用万古霉素并进行血药浓度监测的61例住院患者的临床资料进行回顾性分析。结果：61例患者共监测血药浓度86例次，万古霉素血药浓度＜10 mg／L者48次例（占55.8％），10～15 mg／L者17例次（占19.8％），15～20 mg／L者11例次（占12.8％），＞20 mg／L者10例次（占11.6％），平均血药谷浓度（12.30±10.22） mg／L；万古霉素的血药谷浓度与年龄相关，有随年龄增大而递增的趋势，男女患者间万古霉素血药谷浓度差异不大。结论：临床应加强和重视万古霉素血药浓度监测，结合实际情况调整给药剂量，以期提高临床疗效，保障患者用药安全，促进合理用药。%OBJECTIVE:To investigate the blood concentration monitoring of vancomycin in People 's Hospital of Ma’anshan ( hereinafter referred to as “our hospital”) during 2013-2015, so as to provide reference for the rational application of vancomycinc in clinic .METHODS:The blood concentration of vancomycinc were determined by enzyme -multiplied immunoassay technique , retrospective analysis was conducted on clinical data of 61 inpatients with blood concentration monitoring of vancomycin .RESULTS:86 cases of monitoring were conducted on 61 inpatients , there were 48(55.8%) cases 20 mg/L.The average trough concentration of vancomycin was ( 12.30 ±10.22 ) mg/L.The blood drug concentration was associated with age and increased along with age , but has nothing to do with gender . CONCLUSIONS:The clinic should strengthen and attach more importance to the blood concentration monitoring of vancomycin and adjust the dosage through patients'conditions , so as to improve the clinical efficacy , ensure medication safety and promote the rational drug use .