Phenol compounds especially chlorophenol and nitrophenol compounds in water were determined by SPE-HPLC method. The solid phase extraction (SPE)column was firstly activated by 4 mL methanol and 4 mL pure water, phenol compounds in the sample was absorbed by SPE column, eluted by acetonitrile, and then concentrated to 1 mL. The condition of the HPLC was as follows:pure water and acetonitrile was used as mobile phase and gradient eluted from 8:2 to 2:8, the velocity of flow was 1.0 mL/min. ODS-C18 was used to separate the phenol compounds, the wavelength of the VWD was 285 nm. The linearity of the standard curve was higher than 0.999 0, the detection limits of the phenol compounds was below the requiring of the standard for drinking water quality, the average spike recovery was 70%~90%.%建立了一种固相萃取—高效液相色谱法，测定水中的酚类化合物，特别是氯酚和硝基酚几种酚类化合物。吸附前使用4 mL甲醇和4 mL纯水活化固相萃取小柱（SPE），样品通过SPE时酚类化合物被吸附，后用乙腈洗脱，收集洗脱液浓缩至1 mL。以V 水∶V 乙腈为8∶2梯度淋洗，V 水∶V 乙腈为2∶8结束，流速1.0 mL/min，以ODS-C18分离酚类化合物，检测器波长为285 nm。实验结果表明，标准曲线线性关系均大于0.9990；检出限均小于《生活饮用水卫生标准》的要求；平均加标回收率在70%～90%之间。
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