布拉氏酵母菌预防及治疗婴幼儿抗生素相关性腹泻的临床分析

摘要

Objective: To observe the clinical effect of Boulardii in the prevention and treatment of antibiotic-associated diarrhea in infants and young children. Methods:180 patients were randomly divided into control group and prevention group with 90 cases in each group. Boulardii was administered to the children before antibiotic therapy (prevention), the other 90 children were given Boulardii after diarrhea appeared. The incidence rate of antibiotic-associated diarrhea was compared in the two groups. Result:The incidence rate of diarrhea was 21.11%in the prevention group and 37.78%in the control. The overall response rate was 94.73%in the prevention group and 70.58%in the control group. There was significant difference between the two groups (P<0.05). Conclusion:The use of Boulardii could prevent antibiotic-associated diarrhea and improve the cure rate.%目的：观察布拉氏酵母菌散剂预防及治疗婴幼儿抗生素相关性腹泻的临床疗效。方法：将180例患儿随机分成对照组和预防组各90例，预防组在使用抗生素时即开始口服布拉氏酵母菌，对照组使用抗生素仅在出现腹泻后加服布拉氏酵母菌，两组病例发生腹泻后均加用双八面体蒙脱石散剂口服，重型腹泻者给予补液、补充电解质、纠正酸中毒等对症治疗。观察两组腹泻的发生率及临床疗效。结果：预防组继发腹泻19例，发病率为21.11%，对照组继发腹泻34例，发病率为37.78%；预防组治疗总有效率94.73%，对照组总有效率70.58%，两组患儿在腹泻发生率、腹泻治疗的疗效的比较其差异具有统计学意义(P<0.05)。结论：使用抗生素同时加服布拉氏酵母菌，可降低抗生素相关性腹泻的发生率，提高治愈率。