Objective: To investigate the clinical characteristics and prognosis of drug-induced renal impairment, thus improve the practice of prevention and treatment of it.Methods: 77 cases clinically diagnosed drug-induced renal impairment, were analyzed retrospectively.Results: The drugs which commonly caused drug-induced renal impairment included immunosuppressive drugs (24.7%), traditional Chinese medicine (14.3%), contrast agents (13%), non steroidal anti-inflammatory drugs (11.7%) and antibiotics (11.7%). 51 patients developed acute renal failure, 20 patients were diagnosed chronic renal failure. Of 77 cases of drug-induced renal injury patients, 65 cases were improved, 1 case died, and the improvement rate was 84%.Conclusion:For patients at the risk of renal impairment, factors such as drug dosage, drug duration and pre-existing diseases should be taken into account, and patients should be monitored closely during drug therapies.%目的:探讨药物性肾损害的临床特点及预后,提高药物性肾损害的防治水平.方法:回顾性分析我院2011年2月至2013年12月77例确诊为药物性肾损害住院患者的临床资料.结果:引起药物性肾损害药物主要为免疫抑制剂(24.7%)、中药(14.3%)、造影剂(13%)、非甾体抗炎药(11.7%)、抗菌药(11.7%).77例药物性肾损害患者中,发生急性肾功能衰竭51例,慢性肾功能衰竭20例,慢性肾功能衰竭急性加重6例;65例好转,1例死亡,好转率84%.结论:对于有肾损害危险因素的病人在应用药物时应考虑各方面因素,密切观察用药后反应,监测尿常规、肾功能及尿量的变化.
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