血清C肽与糖化血红蛋白联合检测在2型糖尿病诊断中的临床价值

摘要

目的：探讨血清C 肽与糖化血红蛋白联合检测在2型糖尿病诊断中的临床价值。方法选取该院2013年7月-2014年7月来就诊55例2型糖尿病患者，将其分观察组，并选取同时期正常健康体检者28名为对照组，对其分别进行糖化血红蛋白(HbAlc)、空腹血糖(FBG)、餐后2 h血糖及血清C肽指标进行检测，并对其进行比对。结果观察组糖化血红蛋白(HbAlc)(9.54±1.07)(%)、空腹血糖(FBG)(10.02±2.04)mmol/L、餐后2 h血糖(15.97±1.16)mmol/L、血清C肽(0.87±0.16)μg/L；对照组糖化血红蛋白(HbAlc)(5.28±0.84)%、空腹血糖(FBG)(4.35±0.38)mmol/L、餐后2h血糖(5.59±1.25)mmol/L、血清C肽(1.39±0.22)μg/L。从统计的数据上看，观察组空腹血糖(FBG)、糖化血红蛋白(HbAlc)及餐后2 h血糖明显高于对照组，两组比较差异具有统计学意义(t=18.36、t=14.54、t=37.55、P<0.01)；而观察血清C肽指标明显低于对照组，两组比较差异具有统计学意义(t=12.29、P<0.01)。结论通过对血清C肽和糖化血红蛋白联合进行检测，可以对患者胰岛素分泌情况及病情严重程度做出准确的判断，为临床治疗方案提供可靠科学依据。%Objective To study the serum C peptide and glycosylated hemoglobin examination in the diagnosis of type 2 dia-betes clinical value.Methods Selection our hospital in July 2013 to July 2014 to 55 cases of patients with type 2 diabetes treatment,the observation group, and at the same time normal healthy check-up 28 cases as control group, the respectively are glycosylated hemoglobin (HbAlc), fasting blood glucose (FBG), 2 h postprandial blood glucose and serum c-peptide indi-cators for testing, and carries on the comparison. Results The observation group of glycosylated hemoglobin (HbAlc)(9.54±1.07)(%), fasting blood glucose (FBG)(10.02±2.04)mmol/L , 2 h postprandial blood glucose(15.97±1.16)mmol/L, serum C peptide (0.87±0.16)μg/L;Glycosylated hemoglobin (HbAlc) controls (5.28±0.84)%, fasting blood glucose (FBG)(4.35±0.38)mmol/L, 2 h postprandial blood glucose(5.59±1.25)mmol/L, serum C peptide(1.39±0.22)μg/L.Look from statistical data, observation group fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc) and the postprandial blood glucose 2 h is significantly higher than the control group, two groups of-vice compared statistically significant difference(t=18.36、t=14.54、t=37.55、P<0.01);Serum c-peptide index significantly lower than the control group and observation, is similar between the two groups have statistical significance (t=12.29,P<0.01). Conclusion The serum c-peptide and glycosylated hemoglobin, insulin secretion and the patient can be extent make accurate judgment, provide reliable scientific basis for clinical treatment.