Nonalcoholic fatty liver disease with advanced fibrosis as a multi-systemic disease: proceed with caution

摘要

Accompanying the current epidemics of metabolic syndrome(MS)and obesity caused by westernization of lifestyles,the incidences of non-alcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)have been increasing worldwide over the last few decades(1).Now,NAFLD has a global prevalence estimated at 25%of the world population,with some geographical;the highest prevalences are in the South America and Middle East.Namely,NAFLD has become recognized as the most common liver disease worldwide(2).