Objective In order to guiding the clinical treatment, common bacteria distribution and drug resistance of prostatic fluid were analyzed who suffer from prostatitis. Methods Bacterial cultivation, isolation,drug resistance of 1600 prostatic fluid specimens were used and analyzed. Results 476 strains bacteria from 1600 samples, the positive rate was 26.7%. 482 bacterial strains were isolated, ranked in the top five were Staphylococcus aureus 124 strains, 72 strains of Staphylococcus epidermidis, Escherichia coli62 strains, Enterococcus faecalis strains 56 and 45 strains of Staphylococcus aureus. Drug sensitivity results showed:Staphylococcus methicillin resistant Staphylococcus aureus ( MRSA ) accounted for 20.8%, methicillin resistant coagulase negative staphylococcus ( MRCoN ) accounted for 56.5%, Enterobacteriaceae middle extended-spectrumβ-lactamases ( ESBLs ) strains accounted for 37.1%. Drug resistance of the bacteria to common antibaterials were high. Conclusion Coagulase negative staphylococci is a leading cause of chronic prostatitis of the main bacteria, other were Escherichia coli, Streptococcus faecalis, Staphylococcus aureus. Drug resistance rates of the isolate bacteria to common antibacterials were high, so it is necessary to strengthen the surveillance of antimicrobial resistance, in order to providing basis for clinical rational use of antibiotics, preventtingthe emergence of drug-resistant strains.% 目的分析慢性前列腺炎患者前列腺液培养的细菌分布及常见分离菌的耐药情况，指导临床用药.方法对1600例拟诊为慢性前列腺炎患者的前列腺液进行细菌培养，分离细菌进行生化鉴定和体外药敏试验并加以分析.结果1600份前列腺液标本中有476份分离出细菌，阳性率为26.7%.共分离出细菌482株，居前五位的依次是溶血葡萄球菌124株，表皮葡萄球菌72株、大肠埃希菌62株、粪肠球菌56株及金黄色葡萄球菌45株.药敏结果显示：葡萄球菌中甲氧西林耐药金黄色葡萄球菌(MRSA)占20.8%，甲氧西林耐药凝固酶阴性葡萄球菌(MRCoN)占56.5%，肠杆菌科细菌中产超广谱β-内酰胺酶(ESBLs)的菌株占37.1%，各分离菌对常用抗生素的耐药率较高.结论凝固酶阴性的葡萄球菌是导致慢性前列腺炎的主要细菌，其它分别为大肠埃希菌，粪肠球菌，金黄色葡萄球菌.各分离菌对常用的抗生素均有较高的耐药率，因此必须加强细菌的耐药性监测，为临床合理使用抗生素提供依据，提高疗效，防止耐药菌株的产生.
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