目的：观察帕瑞昔布钠复合地佐辛预防全身麻醉苏醒期躁动的作用。方法全身麻醉下行择期甲状腺切除术患者120例随机均分为帕瑞昔布钠组（P组）、帕瑞昔布钠＋地佐辛组（PD组）、地佐辛组（D组）和等容生理盐水组（C组）4组（n=30）。P组麻醉诱导前静注帕瑞昔布钠40 mg组、PD组麻醉诱导前静注帕瑞昔布钠40 mg并手术结束前30 min静注地佐辛0.1 mg/kg、D组手术结束前30 min静注地佐辛0.1 mg/kg，C组给予等容生理盐水。观察苏醒期躁动的发生情况。结果与C组比较，P、PD、D组苏醒期躁动发生显著减少（P<0.01），BCS分级和Ramsay评分更高（P<0.01），VAS评分更低（P<0.01）；与P组和D组比较，PD组苏醒期躁动发生显著减少（P<0.05或0.01），BCS分级和Ramsay评分更高（P<0.05或0.01），VAS评分更低（P<0.05或0.01）。结论帕瑞昔布钠40 mg复合地佐辛0.1 mg/kg能更好地预防全身麻醉苏醒期躁动，有效提高苏醒期质量。%Objective To observe the effect of parecoxib combined dezocine on preventing agitation during wake-up from general anesthesia. Methods A total of 120 patients undergoing selective thyroidectomy under general anesthesia were randomly divided into 4 groups with 30 cases each. Group P received parecoxib 40 mg iv before induction of anesthesia, group PD received parecoxib 40 mg iv before induction of anesthesia plus dezocine 0.1 mg/kg iv 30 min before the end of operation, group D received dezocine 0.1 mg/kg iv 30 min before the end of operation,group C received equal volume of normal saline. The occurrence of agitation was observed during waking-up period in PACU. Results The rates of agitation was signiifcantly decreased in group s of P,PD and D than that in group of C ,The BCS and Ramsay values were higher and VAS values were lower than that in group of C. Conclusion Parecoxib 40 mg combined 0.1 mg/kg of dezocine can safely and effectively prevent the incidence of emergence agitation, so that to ensure the patients during analqesia period .
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