Objective To investigate effect of laparoscopic and open radical resection on immune function in treat-ment of patients with middle and low rectal cancer. Methods A total of 21 patients with middle and low rectal cancer,who had undergone laparoscopic radical resection,were selected as observation group,and other patients with middle and low rec-tal cancer,who had undergone open radical resection,were selected as control group. Intraoperative and postoperative condi-tions and the immune cell conditions before and after operation were observed and compared in two groups. Results Values of intraoperative volume of blood loss,postoperative anal exhaust time and taking food times and total length of hospital stay in observation group were significantly lower than those in control group (P0.05). At the postoperative 3rdd, CD8+ level was significantly lower than that in control group (P<0.05). Conclusion Laparoscopic radical resection in treatment of patients with middle and low rectal cancer may less affect cellular immune function than that by open radical resection,and it can also reduce intraoperative bleeding volume and shorten the postoperative anus exhaust time,postoperative feeding and the total hospitalization times.%目的 探讨腹腔镜与开腹直肠癌根治术对中低位直肠癌患者免疫功能的影响.方法 选取于腹腔镜下行直肠癌根治术的中低位直肠癌21例作为观察组,另选取同期行开腹直肠癌根治术的中低位直肠癌21例作为对照组,观察比较两组术中、术后情况及手术前后免疫细胞情况.结果 观察组术中出血量、术后肛门排气时间、术后进食时间及总住院时间均明显少于或短于对照组,差异具有统计学意义(P<0.05).术后1 d,观察组CD3+、CD4+及CD4+/CD8+高于对照组,CD8+低于对照组,差异均有统计学意义(P<0.05);术后3 d,观察组CD8+低于对照组,差异具有统计学意义(P<0.05).结论 腹腔镜直肠癌根治术较开腹直肠癌根治术对中低位直肠癌患者细胞免疫功能影响小,且可减少术中出血量,缩短术后肛门排气时间、术后进食时间及总住院时间.
展开▼
