Objective To explore the clinical efficacy of hypertonic saline combined with adrenaline inhalation for the treatment of capillary bronchitis. Methods 200 cases of children with capillary bronchitis admitted to pediatrics department of our hospital from January 2013 to December 2014 were selected and randomly divided into two groups, with 100 cases in each group. Children in the observation group were given epinephrine dissolved in hypertonic saline for inhalation, while children in the control group were given ventolin dissolved in normal saline for inhalation. The time for improvement of clinical symptoms, and changes of number of inflammatory cells were observed and compared. Results The disappearance time of asthma suppress, cough, lung wheeze and moist rales of the observation group were significantly shorter than those of the control group (P<0.05). 5 days after inhalation, the lung function parameters of the observation group were significantly better than those of the control group (P<0.05). The differential values of total number of inflammatory cells, the number of neutrophils and number of lymphocytes before and 5 days after inhalation of the observation group were significantly higher than those of the control group (P<0.05). Conclusions Aerosol inhalation with epinephrine dissolved in hypertonic saline has reliable effect for children with capillary bronchitis, which can shorten the time for improvements of clinical symptoms, reduce the accumulation of inflammatory cells in the airways, and lighten the inflammatory of airway.%目的 探讨高渗盐水配合肾上腺素吸入对毛细支气管炎的临床疗效. 方法 选择2013年1月至2014年12月在我院儿科就诊的毛细支气管炎患儿200例为研究对象, 随机分为观察组和对照组, 每组100例, 观察组将肾上腺素溶于高渗盐水行雾化吸入治疗, 对照组将万托林溶于生理盐水行雾化吸入治疗, 观察并比较两组患儿的临床症状改善所需时间及炎性细胞数量的变化情况. 结果 观察组喘憋、 咳嗽、 肺部喘鸣音及湿啰音的消失时间均明显少于对照组, 差异有统计学意义 (P<0.05). 观察组雾化吸入后5 d患儿的各项肺功能指标均明显优于对照组, 差异有统计学意义 (P<0.05). 两组雾化前后气道分泌物的炎性细胞总数、 中性粒细胞数及淋巴细胞数差值比较, 观察组均明显高于对照组, 差异有统计学意义 (P<0.05). 结论 应用肾上腺素溶于高渗盐水行雾化吸入治疗小儿毛细支气管炎, 可缩短患儿的临床症状改善时间, 有效减少气道炎性细胞的聚积, 减轻气道的炎性反应, 疗效可靠.
展开▼
