血清CRP、IL-6、PCT检测在新生儿败血症诊治中的价值

摘要

目的 探讨联合检测血清白介素-6 (IL-6)、 降钙素原 (PCT)、 C反应蛋白 (CRP) 在新生儿败血症诊治中的价值和意义. 方法 按照随机、 双盲、 对照的原则将2012年2月至2015年2月间来我院新生儿科住院治疗的100例新生儿败血症患儿作为观察组, 抽取同一时间段来新生儿科就诊的100例非败血症患儿作为对照组, 分别检测两组患儿血清CRP、 IL-6、 PCT.结果 观察组患儿的血清CRP、 IL-6、 PCT水平显著高于对照组患儿 (P<0.05); 血清CRP、 IL-6、 PCT联合检测其灵敏度、阳性预测值、 阴性预测值和单一检测相比均显著升高 (P<0.05); 患儿CRP、 IL-6、 PCT和器官功能衰竭评估 (SOFA) 呈正相关, 而和危重评分系统 (PCIS) 评分呈负相关. 结论 临床上对考虑新生儿败血症的患儿应重视对CRP、 IL-6、 PCT的检测, 有利于早期确诊并对病情的严重程度作出判断, 减少不良事件的发生率, 值得临床推广和应用.%Objective To explore the clinical value and significance of combined detection of serum C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) in the diagnosis and treatment of neonatal sepsis. Methods 100 cases of newborns with sepsis in Neonatology Departmen of our hospital from February 2012 to February 2015 were selected as observation group, and 100 cases without sepsis in Neonatology Departmen of our hospitat at the same time were selected as control group. The levels of serum CRP, IL-6 and PCT of the two groups were detected and analyzed. Results The levels of serum CRP, IL-6 and PCT of the observation group were significantly higher than those of the control group (P<0.05). The sensitivity, positive predictive value and negative predictive value of combined detection of three indicators were significantly higher than those of detection of single indicator (P<0.05). The levels of serum CRP, IL-6 and PCT of neonatal sepsis were positively associated with sequential organ failure assessment (SOFA), and negatively associated with pediatric critical illness score (PCIS). Conclusions For newborns with suspected sepsis, the detection of serum of CRP, IL-6 and PCT is conducive to early diagnosis and disease condition assessment, so as to reduce the incidence of adverse events, which is worthy of clinical application.