APOPTOSIS AND TAXOL PRODUCTION IN SUSPENSION CULTURES OF Taxus spp.CELLS

摘要

l.lntroductionSuspension cultures of Taxal chinensis var.mairei frequently accumulate Taxol (paclitaxel),which is clinically effective amineoplanic agent.TSXol is known to act by enhancing thePOlymeriZation of tubulin in the initiation andextension of microtubules, ac has been shown toinduce apoptosis in human and animal cellslll.Apoptosis, also known as programmed cell death, isthe active process of cell death which occurs duringdevelopment and in resPOnse tO enviboental cues ofa multicellular organism. In...